Amine modification of nonporous silica nanoparticles reduces inflammatory response following intratracheal instillation in murine lungs
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چکیده
منابع مشابه
Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation
BACKGROUND The fate of gold nanoparticles, 2, 40 and 100 nm, administered intratracheally to adult female mice was examined. The nanoparticles were traced by autometallography (AMG) at both ultrastructural and light microscopic levels. Also, the gold content was quantified by inductively coupled plasma mass spectrometry (ICP-MS) and neutron activation analysis (NAA). The liver is the major site...
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Background: Neonatal respiratory-distress syndrome (nRDS) is a disease that affects the lung functions in premature infants who are born before their surfactant biosynthetic system has matured. Several surfactant-replacement therapies have been developed and are efficacious in treating the RDS. Objective: The study investigates the inflammatory response of the lung derived cells in rat pups wit...
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OBJECTIVE Titanium dioxide nanoparticles are widely used as UV filters in cosmetics and as a photocatalyst. We evaluated pulmonary responses to different crystal forms of TiO2 nanoparticles. METHODS We used 4 different TiO2 samples with similar specific surface areas (anatase, rutile, amorphous, and P25). Each sample was suspended in distilled water and intratracheally instilled to male Wiste...
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BACKGROUND Declined lung function is a risk factor for particulate matter associated respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD). Carbon nanoparticles (CNP) are a prominent component of outdoor air pollution that causes pulmonary toxicity mainly through inflammation. Recently we demonstrated that mice (C3H/HeJ) with higher than normal pulmonary function res...
متن کاملIntratracheal instillation versus intratracheal inhalation: influence of cytokines on inflammatory response.
Our laboratory has developed a method of particle exposure whereby anesthetized rats intratracheally inhale, at a regulated breathing rate and pressure, an aerosolized test material. This method is capable of delivering considerable doses in a short time period and, unlike the commonly used method of intratracheal instillation, does so with an even particle distribution throughout the lung. Ear...
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ژورنال
عنوان ژورنال: Toxicology Letters
سال: 2016
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2015.11.006